Granulomatous Mycosis Fungoides and Granulomatous Slack Skin

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Granulomatous slack skin: a rare subtype of mycosis fungoides*

We report a case of granulomatous slack skin, a rare and indolent subtype of mycosis fungoides. It affects mainly men between the third and fourth decades. It is characterized by hardened and erithematous plaques that mainly affect flexural areas and become pedunculated after some years. Histological examination shows a dense infiltrate of small atypical lymphocytes involving the dermis (and so...

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Granulomatous slack skin: a distinct disorder or a variant of mycosis fungoides?

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Granulomatous slack skin.

Granulomatous slack skin is an extremely uncommon form of cutaneous T-cell lymphoma. We report a case occurring in a 29-year-old man, who had generalized, progressive skin lesions evolving to nodular swellings and folds in the flexural regions, and peripheral blood and marrow involvement. The biopsies were initially misinterpreted as xanthogranuloma or granulomatous inflammation. Histologically...

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Granulomatous mycosis fungoides - A diagnostic challenge*

Granulomatous mycosis fungoides is a rare subtype of T-cell cutaneous lymphoma. Due to its clinical heterogenicity the diagnosis is delayed and based on histopathological and immuno-histochemical findings, sometimes requiring gene rearrangement studies for confirmation. We report the case of a patient who was submitted to several biopsies before diagnostic conclusion.

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The histological discrimination of granulomatous cutaneous T-cell lymphomas (CTCLs) from reactive granulomatous disorders such as sarcoidosis and granuloma annulare (GA) may be difficult due to overlapping histological features. We analyzed the T-cell receptor gene rearrangement in sarcoidosis and GA to investigate the value of the detection of clonal T cells as an adjunctive diagnostic marker ...

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ژورنال

عنوان ژورنال: Archives of Dermatology

سال: 2008

ISSN: 0003-987X

DOI: 10.1001/archdermatol.2008.46